IGF-DES
Des(1-3) IGF-1 is a truncated analog of human insulin-like growth factor 1 (IGF-1), consisting of 67 amino acids and missing the first three N-terminal residues. This structural modification reduces its affinity for IGF-binding proteins (IGFBPs), allowing for significantly increased biological activity. It is supplied in liquid form with a purity level of ≥99%, and is intended strictly for in-vitro laboratory research.
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Overview
Des(1-3) IGF-1 is being studied for its potent anabolic and regenerative effects, particularly in muscle growth, organ development, and gastrointestinal tissue repair. Its reduced binding to IGFBPs increases its availability to IGF-1 receptors, enhancing its research utility compared to native IGF-1.
Product Research
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Enhanced Cellular Proliferation
Des(1-3) IGF-1 has demonstrated approximately 10 times the potency of native IGF-1 in stimulating hypertrophy and proliferation in cultured cells due to its diminished IGFBP binding [1].
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Anabolic Effects In Vivo
In GH-deficient lit/lit mice, administration of Des(1-3) IGF-1 significantly increased body and organ weights, confirming its role as a potent anabolic agent in growth and tissue development research [2].
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Intestinal Adaptation Post-Resection
In a rat model of extensive bowel resection, Des(1-3) IGF-1 improved weight gain and nitrogen retention, suggesting its utility in studying gastrointestinal repair and adaptation [3].
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IGF Axis Modulation in Muscle Tissue
Des(1-3) IGF-1 was found to reduce IGFBP-3 levels in cultured porcine myogenic cells, indicating it may play a role in promoting differentiation and muscle cell maturation [4].
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Research in Cancer Cell Biology
Des(1-3) IGF-1 has been shown to mimic IGF-II activity in colon carcinoma cells, promoting differentiation and offering a model to study growth factor regulation in cancer [5].
Disclaimer
This product is intended for laboratory research and development purposes only. It is not approved for human consumption, medical, or veterinary use. All data is for informational purposes only and should be used under supervision in controlled laboratory environments by qualified professionals.
Referenced Citations
- Potentiation of IGF-1 effects by altering binding protein affinity – PubMed
- In vivo effects of des(1-3) IGF-I in GH-deficient mice – PubMed
- Effect of IGF-I on gut adaptation and growth after small bowel resection – PubMed
- Des(1-3) IGF-I downregulates IGFBP-3 in porcine muscle cells – PubMed
- Des(1-3) IGF-I promotes differentiation in human colon carcinoma cells – PubMed
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Overview
Des(1-3) IGF-1 is being studied for its potent anabolic and regenerative effects, particularly in muscle growth, organ development, and gastrointestinal tissue repair. Its reduced binding to IGFBPs increases its availability to IGF-1 receptors, enhancing its research utility compared to native IGF-1.
Product Research
-
Enhanced Cellular Proliferation
Des(1-3) IGF-1 has demonstrated approximately 10 times the potency of native IGF-1 in stimulating hypertrophy and proliferation in cultured cells due to its diminished IGFBP binding [1].
-
Anabolic Effects In Vivo
In GH-deficient lit/lit mice, administration of Des(1-3) IGF-1 significantly increased body and organ weights, confirming its role as a potent anabolic agent in growth and tissue development research [2].
-
Intestinal Adaptation Post-Resection
In a rat model of extensive bowel resection, Des(1-3) IGF-1 improved weight gain and nitrogen retention, suggesting its utility in studying gastrointestinal repair and adaptation [3].
-
IGF Axis Modulation in Muscle Tissue
Des(1-3) IGF-1 was found to reduce IGFBP-3 levels in cultured porcine myogenic cells, indicating it may play a role in promoting differentiation and muscle cell maturation [4].
-
Research in Cancer Cell Biology
Des(1-3) IGF-1 has been shown to mimic IGF-II activity in colon carcinoma cells, promoting differentiation and offering a model to study growth factor regulation in cancer [5].
Disclaimer
This product is intended for laboratory research and development purposes only. It is not approved for human consumption, medical, or veterinary use. All data is for informational purposes only and should be used under supervision in controlled laboratory environments by qualified professionals.
Referenced Citations
- Potentiation of IGF-1 effects by altering binding protein affinity – PubMed
- In vivo effects of des(1-3) IGF-I in GH-deficient mice – PubMed
- Effect of IGF-I on gut adaptation and growth after small bowel resection – PubMed
- Des(1-3) IGF-I downregulates IGFBP-3 in porcine muscle cells – PubMed
- Des(1-3) IGF-I promotes differentiation in human colon carcinoma cells – PubMed
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