Melanotan II (MT)
Melanotan II (MT-II) is a synthetic cyclic heptapeptide and analog of alpha-Melanocyte-Stimulating Hormone (α-MSH). It is a non-selective agonist of melanocortin receptors, including MC1, MC3, MC4, and MC5. This peptide is supplied in liquid form with a purity level of ≥99%, making it suitable for in-vitro and laboratory research purposes.
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Overview
Melanotan II is currently being researched for its roles in modulating skin pigmentation and sexual function. Its mechanism of action is tied to stimulation of melanocortin receptors, which may influence melanin production and central nervous system functions.
Product Research
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Skin Pigmentation
Melanotan II has been shown to stimulate melanin production, leading to increased skin pigmentation. In a phase I clinical study, participants exhibited darker skin with limited UV exposure [1].
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Erectile Dysfunction
In men with psychogenic erectile dysfunction, Melanotan II was observed to initiate spontaneous erections. A placebo-controlled crossover study demonstrated that MT-II induced erectile responses in the majority of participants [2].
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Female Sexual Dysfunction
Animal studies on ovariectomized rats demonstrated that MT-II administration led to increased proceptive sexual behaviors. These findings suggest potential relevance in female sexual dysfunction models [3].
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Adverse Effects and Safety
Case reports and toxicology studies have raised concerns regarding adverse effects of MT-II. These include nausea, flushing, and in some instances, systemic toxicity and rhabdomyolysis. There are also concerns about potential links to melanoma [4][5].
Disclaimer
This product is intended for laboratory research and development purposes only. It is not approved for human consumption, medical, or veterinary use. The information provided is for scientific reference only and should be used under the supervision of qualified professionals in controlled laboratory settings.
Referenced Citations
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study – PubMed
- Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo-controlled crossover study – PubMed
- The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in female rats – PubMed
- Melanotan II injection resulting in systemic toxicity and rhabdomyolysis – PubMed
- Melanoma associated with the use of melanotan-II – PubMed
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Overview
Melanotan II is currently being researched for its roles in modulating skin pigmentation and sexual function. Its mechanism of action is tied to stimulation of melanocortin receptors, which may influence melanin production and central nervous system functions.
Product Research
-
Skin Pigmentation
Melanotan II has been shown to stimulate melanin production, leading to increased skin pigmentation. In a phase I clinical study, participants exhibited darker skin with limited UV exposure [1].
-
Erectile Dysfunction
In men with psychogenic erectile dysfunction, Melanotan II was observed to initiate spontaneous erections. A placebo-controlled crossover study demonstrated that MT-II induced erectile responses in the majority of participants [2].
-
Female Sexual Dysfunction
Animal studies on ovariectomized rats demonstrated that MT-II administration led to increased proceptive sexual behaviors. These findings suggest potential relevance in female sexual dysfunction models [3].
-
Adverse Effects and Safety
Case reports and toxicology studies have raised concerns regarding adverse effects of MT-II. These include nausea, flushing, and in some instances, systemic toxicity and rhabdomyolysis. There are also concerns about potential links to melanoma [4][5].
Disclaimer
This product is intended for laboratory research and development purposes only. It is not approved for human consumption, medical, or veterinary use. The information provided is for scientific reference only and should be used under the supervision of qualified professionals in controlled laboratory settings.
Referenced Citations
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study – PubMed
- Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo-controlled crossover study – PubMed
- The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in female rats – PubMed
- Melanotan II injection resulting in systemic toxicity and rhabdomyolysis – PubMed
- Melanoma associated with the use of melanotan-II – PubMed
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